Epidemiology of hepatitis C: related hepatocellular carcinoma in Cameroon

Epidemiology of hepatitis C: related hepatocellular carcinoma in Cameroon

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INTRODUCTION: hepatocellular carcinoma (HCC) is a global public health problem.Hepatitis C virus (HCV) infection accounts for close Wine Racks to 24% of HCC in developing countries especially when associated with cirrhosis.There exists no vaccine against HCV to prevent the occurrence of HCV-related HCC.A sound knowledge of the epidemiology and prevention of the initial infection is vital.

The aim of our study was to determine the epidemiologic profile of HCV-related HCC in Cameroon to improve its management.METHODS: it was a prospective study of histologically proven HCV-related HCC seen in two University Centers in Yaounde, Cameroon from March 2012 to January 2013.Demographic data (age, gender), alcohol abuse (=80g/day), presence of cirrhosis, tobacco abuse and parenteral exposition were analyzed.RESULTS: twenty-six patients with histologically proven HCV related HCC were included (18 men (69.

2%) and 8 women (30.8%); mean age +/- SD, 61.46+/-10.18 years).

A total of 22 (84.6%) patients had a parenteral exposition, 02 (7.7%) patients were alcoholics and 06 (23.1%) patients were smokers.

The proportion of patients with cirrhosis was 69.2% against 30.8% cirrhosis-free.Patients with cirrhosis were relatively younger than those cirrhosis-free (mean age +/- SD, 59.

05+/-10.05 Burdock Root years vs 66.87+/- 8.72 years, p=0.

06).HCV-related HCC was more prevalent in 60 years and above patients (53.8%, 95%CI: 33.4-73.

4).The relative risk of HCC among alcoholics patients was high (RR: 1.5, 95%CI: 1.13-1.

99, p=0.05).